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When you take supplements like VITAcure METHYL PLUS and SAM-e and other supplements with high active nutritional content (but no water), your body will need more water than before. Besides, increased methylation also increases the need to hydrate. Drink several times during the day (drinking everything at once does not help much). Failure to do so will often cause dehydration. If you get headaches, this is usually the cause. Being dehydrated over time can cause other problems.

The omega-3 fatty acids are essential for brain and other bodily functions. Unfortunately, our diet often consists of too much omega-6 compared to omega-3. Though our ancestors evolved on about equal amounts of omega-3 and omega-6 fats, Americans today get 10 to 25 times more omega-6s than omega-3s. The balance is important. Add more omega-3 and replace oils with the highest omega-6 content.

A: Could be no problem to take other multivitamins, but it depends what vitamins. If there is a high dose of some B-vitamins and Folate, it could affect undermethylators negatively. Other vitamins are usually no problem.

A: It depends but could be from a few weeks to several months. If you take with SAM-e in the beginning, it should be faster than without them. For some, however, the results can come soon without also, and for others (more undermethylated), SAM-e is necessary to notice significant improvement.